长时间工作记忆任务中COMT多态性与ERP的关联研究

Associated Study on ERP and COMT Genotype in Continuous Working Memory Tasks

DOI：

中文关键词:COMT(Catechol-O-Methyltransferase) 视觉 P3 工作记忆

英文关键词:COMT (Catechol-O-Methyl-transferase) visual P3 working memory

基金项目:

作者	单位
王政	苏州大学
岳春林	四川大学华西基础医学院生物医学工程专业

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中文摘要:

针对不同COMT基因型的被试者，首次利用视觉事件相关电位P3来观测被试者在长时间心算任务中COMT基因多态型与脑皮层电生理的关系。选取20名不同基因型人员作为被试者，在执行9组不同难度的心算任务后即刻，进行5 min的3-back任务，探讨健康成人数字工作记忆能力变化情况。Val/Val基因型的被试者P3波幅显著高于Val/Met基因型（P<0.01），但和Met/Met基因型被试者的波幅无差异；Val/Met基因型被试者在不同的工作记忆任务中都显示了最差的成绩。

英文摘要:

It was the first to use P3 visual event-related potentials to explore the relationships between COMT polymorphism and cortical physiology in mental arithmetic tasks for a long time. 20 different genotype subjects were chosen for 9-group mental arithmetic work of different workload, followed immediately by 5 minutes' 3-back task so as to observe the changes of numerical working memory ability of healthy adults. P3 amplitude of the subjects with Val/Val homozygote is significantly higher than the subjects with Val/Met homozygote(P<0.01). But compared to the subjects with Met/Met homozygote, there is no distinct significance in P3 amplitude. Val/Met heterozygous individuals show poorer performance compared to those with other genotypes.

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