Tendinopathy is caused by overuse which results in fatigue damage. The paper makes it clear that molecule response of tendon under repeated load will not only help understand the progress of tendinopathy, but also help find the new measures for prevention, treatment and rehabilitation. The paper elaborates on the tendon collagen synthesis and the function of growth factors after exercise and under fatigue load in order to investigate the early molecular mechanism of tendon fatigue damage. Diverse responses of collagen subtypes, as well as the dose-dependency of load, are observed after different exercise and under different fatigue load. In response to mechanical stimulation, some growth factors such as TGFβ-1, IGF-I and IL-6 may play a vital role of regulation. |