胰岛素信号通路在运动改善阿尔茨海默病中的作用机制

The Mechanism of Insulin Signaling Pathway in the Improvement of Alzheimer's Disease by Exercise

DOI：10.12064/ssr.20210504

英文关键词:Alzheimer's disease insulin signaling pathway exercise

基金项目:

作者	单位
任鹏飞	山东大学体育学院,山东济南 250061 。

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中文摘要:

阿尔茨海默病(AD)是目前最为常见的痴呆类型，其发病机制复杂，尚未完全阐明。研究发现，胰岛素信号通路在AD发病机制中发挥重要作用。运动可以通过激活胰岛素信号通路，调控下游分子表达，改善AD病理表现。从磷脂酰肌醇-3-激酶/丝苏氨酸激酶(PI3K/AKT)、丝裂原活化蛋白酶(MAPK)和Wnt 3条胰岛素信号通路视角切入，探讨运动改善AD的可能分子机制，为AD治疗提供理论依据。

英文摘要:

Alzheimer's Disease (AD) is the most common type of dementia at present. Its pathogenesis is complex and has not been fully elucidated. Studies have shown that insulin signaling pathway plays an important role in the pathogenesis of AD. Exercise can improve the pathological manifestations of AD by activating insulin signaling pathway and regulating the expression of downstream molecules. In this study, the phosphatidylinositol-3- kinases/serine threonine kinase (PI3K/AKT), mitogen-activated protein kinase (MAPK) and Wnt3 insulin signaling pathways were examined to explore the possible molecular mechanism of exercise in improving AD, and to provide theoretical basis for the treatment of AD.

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