| Parkinson's disease (PD) is a common degenerative disease of the central nervous system that critically affects the health of the elderly. PD patients exhibit typical motor dysfunction. As the disease progresses, patients suffer from dementia. Currently, there is no drug that can cure cognitive impairment in PD. Evidences show that exercise can not only alleviate motor dysfunction, but also promote hippocampal neurogenesis and improve cognitive function, but we don't know the precise mechanism. Latest researches reported that exercise can significantly improve the pathology of PD, including reducing the accumulation of α-synuclein (α-syn), reducing central inflammation, promoting the release of neurotrophic factors and transmitters, etc, which consequently improved the damaged hippocampal microenvironment, restored its ability to neurogenesis, and improved memory and cognitive function. As the regulatory mechanisms are complex, the aim of this report is to discuss which molecular pathway can be involved in exercise to promote neurogenesis and improve cognitive function, so as to increase the understanding of the mechanism of improving cognitive function through exercise in PD patients, and provide a theoretical basis for exercise intervention in PD cognitive function decline. |
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