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| 肌腱疲劳性损伤与胶原合成 |
| Tendon fatigue damage and collagen synthesis |
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| DOI： |
| 中文关键词:肌腱 疲劳性损伤 胶原 |
| 英文关键词:tendon fatigue damage collagen |
| 基金项目: |
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| 中文摘要: |
| 腱病主要是因为过度使用所导致的疲劳性损伤，明确重复负载下肌腱中分子反应不仅有利于理解腱病发展，而且有利于发现新的预防、治疗和康复措施。本文综述了运动后和疲劳负载下，肌腱中胶原的合成和生长因子的作用，以探讨肌腱疲劳性损伤早期的分子机制。资料研究表明，不同运动和疲劳负载下肌腱中胶原亚型表达不同，并具有载荷剂量依赖性；在这些机械刺激下一些生长因子如生长因子（TGFβ-1）、胰岛素生长因子（IGF-I）、白介素-6（IL-6）等可能起到重要的调节作用。 |
| 英文摘要: |
| Tendinopathy is caused by overuse which results in fatigue damage. The paper makes it clear that molecule response of tendon under repeated load will not only help understand the progress of tendinopathy, but also help find the new measures for prevention, treatment and rehabilitation. The paper elaborates on the tendon collagen synthesis and the function of growth factors after exercise and under fatigue load in order to investigate the early molecular mechanism of tendon fatigue damage. Diverse responses of collagen subtypes, as well as the dose-dependency of load, are observed after different exercise and under different fatigue load. In response to mechanical stimulation, some growth factors such as TGFβ-1, IGF-I and IL-6 may play a vital role of regulation. |
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