|
| 力竭运动恢复期大鼠纹状体微透析液中DA、5-HT及其代谢物的动态变化 |
| Dynamic changes of DA, 5-HT and their metabolism in the striatum of rat brain in the recovery period after exhaustive exercise |
| |
| DOI： |
| 中文关键词:微透析 纹状体 运动中枢疲劳 多巴胺 5-羟色胺 |
| 英文关键词:micro-dialysis striatum exercise-induced central fatigue DA 5-HT |
| 基金项目:江苏省科技厅自然科学基金项目（BK2011863） |
|
| Hits: 3160 |
| Download times: 3852 |
| 中文摘要: |
| 通过微透析采样技术，观察大鼠力竭运动后恢复期不同时段纹状体细胞外液多巴胺（DA）、5-羟色胺（5-HT）含量及其代谢的动态变化，分析运动恢复期DA和5-HT的变化特点与相互关系，为探索运动性中枢疲劳和恢复机制提供实验依据。研究发现：力竭运动恢复期不仅大鼠纹状体DA、5-HT和5-HIAA的代谢恢复具有延迟性，其释放恢复也都具有延迟性，力竭运动后24 h恢复仍未完成；力竭运动恢复期中大鼠纹状体细胞外5-HIAA含量变化与细胞外5-HT含量变化具有同步性，但变化没有5-HT显著；大鼠纹状体细胞外DA/5-HT显著低于安静水平，24 h恢复期抑制性神经递质仍起主导作用；运动疲劳产生时纹状体细胞外DA和5-HT含量的变化较其总量变化更加敏感，提示使用微透析监控中枢细胞外液中DA和5-HT含量的变化可以更加敏感、可靠地评价运动性中枢疲劳。 |
| 英文摘要: |
| Through the micro-dialysis sampling technique, the author tries to observe the changes of extracellular dopamine (DA) and 5- hydroxytryptamine (5-HT) as well as their metabolism in the striatum after exhaustive exercise and analyzes the variation characteristics of DA and 5-HT and the interrelations between them in order to provide experimental basis for exploring the mechanism of exercise-induced central fatigue and recovery. The result shows that in the recovery period after exhaustive exercise, not only DA, 5-HT and the metabolism of 5-HIAA show retardation, but the release of recovery also delays. The recovery cannot be completed at the 24 hours after exercise. The changes of 5-HIAA in the recovery period after exhaustive exercise take place simultaneously with those of 5-HT, but not as significantly as 5-HT. DA/5-HT is significantly lower than that in the state of quietness. Inhibitory neurotransmitter still plays a leading role in the 24-hour recovery period. When exercise-induced fatigue occurs, the changes of DA and 5-HT are more sensitive compared to the changes of their total amount. This indicates that adopting micro-dialysis to monitor the changes of DA and 5-HT may evaluate central fatigue more sensitively and reliably. |
| View Full Text View/Add Comment Download PDF reader |
| Close |
