运动促进神经再生在改善帕金森病认知障碍的机制

Exercise Promotes Neurogenesis in Improving the Mechanism of Cognitive Impairment in Parkinson’s Disease

DOI：10.12064/ssr.2023122501

英文关键词:neurogenesis exercise cognition Parkinson's disease

基金项目:

Author Name	Affiliation
SUN Yu	School of Physical Education, Yangzhou University, Yangzhou 225127 , China
ZHANG Xin	School of Physical Education, Yangzhou University, Yangzhou 225127 , China
LI Nan	School of Physical Education, Yangzhou University, Yangzhou 225127 , China
XU Haocheng	School of Physical Education, Yangzhou University, Yangzhou 225127 , China
SUN Xun	School of Physical Education, Yangzhou University, Yangzhou 225127 , China
ZHAO Renqing	School of Physical Education, Yangzhou University, Yangzhou 225127 , China

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中文摘要:

帕金森病（PD）是生活中常见的严重影响老年人健康的中枢神经系统退行性疾病。PD患者表现出典型的运动功能障碍，随着病情的发展，还可能出现痴呆症状。目前尚无药物可以治愈PD患者的认知障碍。大量证据表明，运动不但可以缓解运动功能障碍，还能促进海马神经再生、改善认知功能，但其调控机制并不清楚。最新研究报道，运动干预可明显改善PD相关的病理因素，包括减少α-突触核蛋白（α-syn）堆积、减轻中枢炎症、促进神经营养因子与递质释放等，从而改善受损的海马区微环境，恢复其神经再生能力，提高记忆与认知功能。鉴于相关调控机制复杂，旨在阐明哪些分子通路可参与运动促进神经再生改善认知功能，以增加对运动改善PD患者认知功能的机制认识，为运动干预PD认知功能下降提供理论依据。

英文摘要:

Parkinson's disease (PD) is a common degenerative disease of the central nervous system that critically affects the health of the elderly. PD patients exhibit typical motor dysfunction. As the disease progresses, patients suffer from dementia. Currently, there is no drug that can cure cognitive impairment in PD. Evidences show that exercise can not only alleviate motor dysfunction, but also promote hippocampal neurogenesis and improve cognitive function, but we don't know the precise mechanism. Latest researches reported that exercise can significantly improve the pathology of PD, including reducing the accumulation of α-synuclein (α-syn), reducing central inflammation, promoting the release of neurotrophic factors and transmitters, etc, which consequently improved the damaged hippocampal microenvironment, restored its ability to neurogenesis, and improved memory and cognitive function. As the regulatory mechanisms are complex, the aim of this report is to discuss which molecular pathway can be involved in exercise to promote neurogenesis and improve cognitive function, so as to increase the understanding of the mechanism of improving cognitive function through exercise in PD patients, and provide a theoretical basis for exercise intervention in PD cognitive function decline.

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